Handle length and thickness are usually selected to fit the user's hand. The handle should be slightly longer than width of the palm. Nesmuk knife handles have an oval cross-section and a harmonious, 'hand-friendly' shape. This enables different 'grips' and makes them comfortable to use for long periods of time, even when strong pressure is being exerted. The handles are all solid.

A selection of professionally stored, fine woods and micarta are available for use as the handle material.